I like reading Rupert Sheldrake essays. He does such a direct exposé of the weaknesses of science. Oh, I am not a science basher. That is not the reason I like him. I wish the very best for science. And I know he does, too. At the same time I know that in many ways science is on the wrong track, and I am glad that, in Sheldrake, I have such a fellow frank-speaking well-wisher.
The latest new thing for me that Sheldrake points out is something called the “missing heritability problem.” Ever heard of it? Not me.
Wiki has only a VERY short article, which I can post in full here:
The “missing heritability” problem[1][2][3][4][5] can be defined as the fact that individual genes cannot account for much of the heritability of diseases, behaviors, and other phenotypes. This is a problem that has significant implications for medicine, since a person’s susceptibility to disease may depend more on “the combined effect of all the genes in the background than on the disease genes in the foreground”.
A model has been introduced that takes into account epigenetic inheritance on the risk and recurrence risk of a complex disease.[4]
The limiting pathway (LP) model has been introduced in which a trait depends on the value of k inputs that can have rate limitations due to stoichiometric ratios, reactants required in a biochemical pathway, or proteins required for transcription of a gene. Each of these k inputs is a strictly additive trait that depends on a set of common or rare variants. When k = 1, the LP model is simply a standard additive trait.[2]
First of all, this is A BIG DEAL.
Secondly, as with all unsolved mysteries of science (the ones they cannot sweep under the carpet), the solution is “just round the corner.” Like fusion, dark matter, dark energy, the Younger Dryas stadial (climate), the “divergence problem” in climate proxies (which no longer show any correlation between tree rings and global temperatures), and also the origin of life. The solutions to all of those are just around the corner. Continue reading